Drugs Acting on the Digestive System Quiz 2

This post is a pharmacology quiz on drugs acting on the digestive system. With challenging pharmacology questions and engaging pharmacology quizzes, this blog post is an essential resource for anyone seeking to improve their understanding of drugs acting on the digestive system.

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Drugs Acting on the Digestive System Quiz 2

1 / 21

1. What is true of acid control therapy with H2 blockers:

A. It checks bleeding in case of bleeding peptic ulcer

B. Both ‘A’ and ‘B’ are correct

C. It prevents gastroesophageal reflux

D. It generally heals duodenal ulcers faster than gastric ulcers

2 / 21

2. In the intact animal H2 receptor antagonists potentiate the following action of histamine

A. Fall in blood pressure

B. Cardiac stimulation

C. Uterine relaxation

D. Bronchospasm

3 / 21

3. Gynaecomastia can occur as a side effect of:

A. Bromocriptine

B. Cimetidine

C. Famotidine

D. Levodopa

4 / 21

4. For healing duodenal ulcer the usual duration of H2
blocker therapy is:

A. 4 weeks

B. 12 weeks

C. 6 weeks

D. 8 weeks

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5. As an antacid, sodium bicarbonate has the following
disadvantages except:

A. It has low acid neutralizing capacity

B. It causes acid rebound

C. In ulcer patients, it increases risk of perforation

D. It is contraindicated in hypertensives

6 / 21

6. The following is true of proton pump inhibitors except:

A. Their prolonged use can cause atrophy of gastric mucosa

B. They have no effect on gastric motility

C. They are the most effective drugs for Zolinger Ellison syndrome

D. They inhibit growth of H. pylori in stomach

7 / 21

7. Choose the drug which blocks basal as well as
stimulated gastric acid secretion without affecting
cholinergic, histaminergic or gastrin receptors:

A. Omeprazole

B. Pirenzepine

C. Loxatidine

D. Famotidine

8 / 21

8. The most efficacious drug for inhibiting round the
clock gastric acid output is:

A. Pirenzepine

B. Cimetidine

C. Pirenzepine

D. Omeprazole

9 / 21

9. Which histamine H2 blocker has most marked
inhibitory effect on microsomal cytochrome P-450
enzyme:

A. Ranitidine

B. Famotidine

C. Cimetidine

D. Roxatidine

10 / 21

10. The following is true of proton pump inhibitors except:

A. They are the most effective drugs for Zolinger Ellison syndrome

B. Their prolonged use can cause atrophy of gastric mucosa

C. They inhibit growth of H. pylori in stomach

D. They have no effect on gastric motility

11 / 21

11. The following statement is true about misoprostol:

A. It produces fewer side effects than H2 blockers

B. It relieves peptic ulcer pain, but does not promote ulcer healing

C. It heals nonsteroidal anti-inflammatory drug induced gastric ulcer not responding to H2 blockers

D. It is the most effective drug for preventing ulcer relapse

12 / 21

12. Omeprazole exerts practically no other action except
inhibition of gastric acid secretion because:

A. It transforms into the active cationic forms only in the acidic pH of the gastric juice

B. Its active forms have selective affinity for the H+K+ATPase located in the apical canaliculi of gastric parietal cells

C. All of the above

D. Its cationic forms are unable to diffuse out from the gastric parietal cell canaliculi

13 / 21

13. Ranitidine differs from cimetidine in the following respect:

A. It does not have antiandrogenic action

B. It produces more CNS side effects

C. It is less potent

D. It is shorter acting

14 / 21

14. Choose the antiulcer drug that inhibits gastric acid
secretion, stimulates gastric mucus and bicarbonate
secretion and has cytoprotective action on gastric
mucosa:

A. Sucralfate

B. Carbenoxolone sodium

C. Colloidal bismuth subcitrate

D. Misoprostol

15 / 21

15. Choose the correct statement about H2 receptor
blockers:

A. They cause fastest healing of duodenal ulcers

B. They prevent stress ulcers in the stomach

C. They are the most efficacious drugs in inhibiting gastric acid secretion

D. They afford most prompt relief of ulcer pain

16 / 21

16. The ‘acid neutralizing capacity’ of an antacid is
governed by:

A. The equivalent weight of the antacid

B. Both ‘A’ and ‘C’

C. The rate at which the antacid reacts with HCl

D. The pH of 1N solution of the antacid

17 / 21

17. Compared to H2 blockers, omeprazole affords the
following:

A. Faster healing of duodenal ulcer

B. Faster relief of ulcer pain

C. Higher efficacy in healing reflux esophagitis

D. All of the above

18 / 21

18. Select the drug which is an inhibitor of gastric mucosal
proton pump:

A. Carbenoxolone sodium

B. Sucralfate

C. Famotidine

D. Lansoprazole

19 / 21

19. The primary mechanism by which prostaglandins
promote ulcer healing is:

A. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa

B. Inhibition of gastric acid secretion

C. Increased turnover of gastric mucosal cell

D. Increased bicarbonate secretion in gastric juice

20 / 21

20. The following class of gastric antisecretory drug also
reduce gastric motility and have primary effect on
juice volume, with less marked effect on acid and
pepsin content:

A. Histamine H2 blockers

B. Prostaglandins

C. Anticholinergics

D. Proton pump inhibitors

21 / 21

21. Histamine H2 blockers attenuate the gastric secretory
response to acetylcholine and pentagastrin as well
because:

A. H2 blockers inhibit the proton pump in gastric mucosa

B. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well

C. Histamine, acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa

D. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa

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April 25, 2023

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